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Pepsin A, powder

Pepsin is an acid protease. Its inactive zymogen precursor, pepsinogen, is produced in the stomach mucosa. There are several pepsins designated A, B, C, and D. Pepsin A, the major component, has a molecular weight of 35,000 daltons and an optimum pH for enzymatic activity of approximately 1.0 for substrates such as casein or hemoglobin if the substrate is native protein. Pepsin cleaves proteins preferentially at the carboxylic groups of aromatic amino acids such as phenylalanine and tyrosine. It will not cleave at bonds containing valine, alanine, or glycine. Pepsinogen activates to pepsin below pH 5. Pepsin is unstable above pH 6.

Source: Porcine stomach
2X crystallized from dilute alcohol; lyophilized powder
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